Treatment Guidelines
Listed below are a number of frequently used local treatment guidelines. Please use the search function above if the guideline you require is not listed. Alternatively, search for treatment guidelines hosted on the GHNHSFT intranet (intranet access required).
On this page
1 Gastrointestinal System
Andexanet alfa (Ondexxya®) for reversing rivaroxaban or apixaban in acute, life-threatening G.I. bleeds
Ciclosporin for acute severe Ulcerative Colitis
Inflammatory Bowel Disease (IBD) Biologics Pathway
Proton Pump Inhibitors (PPI) - Oral
Proton Pump Inhibitors (PPI) - Intravenous
Terlipressin for variceal bleeding / hepato-renal syndrome
2 Cardiovascular System
Adenosine infusion (for Fractional Flow Reserve testing)
Andexanet alfa (Ondexxya®) for reversing apixaban, edoxaban, or rivaroxaban or in acute, life-threatening G.I. bleeds
Anticoagulants (oral) - management of bleeding
Contrast-induced Nephropathy Prophylaxis
DC cardioversion for AF on CCU
Digoxin - being updated
Direct Oral Anticoagulant (DOAC) 'Bridging' Protocol - Management of DOACs / NOACs During Elective Procedures
DOAC reversal for acute, life-threatening bleeds
Fluid Resuscitation - intranet
HbA1c testing and glucose control in ACS
Heparin (unfractionated) infusion
Idarucizumab (Praxbind®) for reversing dabigatran in acute, life-threatening bleeds
Iloprost for Critical Ischaemia or Severe Raynaud’s Phenomenon - intranet
Labetalol infusion chart - intranet
Lipid Pathway (secondary prevention)
Noradrenaline (peripheral infusion)
Post-Carotid Endarterectomy Hypertension management
Prophylaxis/Treatment of VTE in COVID-19
Prophylaxis/Treatment of VTE in renal impairment
Thrombolysis options during Alteplase shortage
Thrombolysis of Massive Pulmonary Embolus (PE) - intranet
Thrombolysis of STEMI (contingency 2020)
Warfarin 'Bridging' Protocol - Management of Warfarin During Elective Procedures
3 Respiratory System
Intrapleural Fibrinolytics for Pleural Infection (alteplase & dornase alfa)
Pulmonary Embolism - intranet
Thrombolysis of Massive Pulmonary Embolus (PE) - intranet
Non-Invasive Ventilation for Acute Hypercapnic Respiratory Failure - intranet
High Flow Nasal Oxygen - intranet
Tuberculosis screening for Biologic and Immunomodulatory drugs for inflammatory conditions
4 Nervous System
ADHD Medication Supply Shortage
Alcohol Detoxification - intranet
Anti-emetics choice of therapy (paediatric) - intranet
Apomorphine in Parkinson's Disease
Dementia agitation pathway - G-Care
Domperidone - MHRA restrictions
Emergency Sedation (formerly Rapid Tranquillisation) - intranet
Ketamine (multimodal analgesia) - intranet
Morphine Allergy - Pain Treatment - intranet
Naloxone - intranet
Neuropathic Pain - being updated
Nicotine Replacement Therapy (NRT) - inpatients (non-pregnant)
Nicotine Replacement Therapy (NRT) - inpatients (pregnant)
Management of Opioid Users (inpatients) - intranet
Paracetamol (i.v.) prescribing criteria
Paracetamol: Weight-adjusted dosing (adults)
Parkinson's Disease - Medicines Management in Inpatients
Post-operative Nausea & Vomiting (PONV) - intranet
Status Epilepticus - intranet
5 Infection
6 Endocrine System
Type 2 Diabetes Treatment Guideline - being updated
Diabetic Ketoacidosis - intranet
Hypoglycaemia - intranet
Peri-operative Diabetes Management - intranet
7 Genito-urinary System
8 Immune System and Malignant Disease
Anaemia and Iron Deficiency in Oncology Patients
Bone Protection in High Grade Lymphoma
Cytokine Release Syndrome Treatment Guideline
Darbepoetin Alfa for anaemia in patients receiving chemotherapy
Anaemia and Iron Deficiency in Oncology Patients
Glucarpidase for methotrexate-induced renal dysfunction
ICANS (Immune Cell Associated Neurotoxicity Syndrome) Guideline
Immune-related Diarrhoea & Colitis
Management of Immune-related Adverse Events (IrAEs) Caused by immunotherapy
Management of Skin Toxicity Related to Parenteral Anti-EGFR Treatment for Colorectal Cancer
Mosunetuzumab Treatment Guideline
Tebentafusp for the Treatment of Metastatic Uveal Melanoma in HLA-A*02:01 Positive Patients
Tumour Lysis Syndrome - intranet
Prescription & Monitoring of High Dose Corticosteroids in Oncology Inpatients
9 Blood and Nutrition
Hypercalcaemia (tumour-induced)
Cosmofer® (iron dextran) total dose infusion guideline
Cosmofer® (iron dextran) administration - see Medusa or sample drug chart
Diafer® (iron isomaltose) administration - see Medusa
Ferinject® (ferric carboxymaltose) administration - see Medusa or sample drug chart
Monofer® (iron[III] isomaltoside 1000) administration - see Medusa or sample drug chart
Preoperative management of anaemia
Anaemia and Iron Deficiency in Oncology Patients
Vitamin B12 deficiency treatment
Vitamin D prescribing guidance - Primary Care
Vitamin D prescribing guidance - Secondary Care
Vitamin D Rapid Loading: Bone Health Specialist Protocol - Inpatient use only
Intravenous Fluid Management – intranet
10 Musculoskeletal System
11 Eye
12 Ear, nose & oropharynx
Mouthcare Guideline - intranet
13 Skin
14 Vaccines
15 Anaesthesia
16 Transfusion Medicine
Blood Transfusion Policy (intranet)
Management of Major Haemorrhage SOP – including Action Cards for ACRT, Porters, Site Team and Emergency Theatre Co-ordinator
ROTEM interpretation algorithm
Transfusion Reactions (intranet)
Special requirements for transfusion (intranet)
Direct Oral Anticoagulant (DOAC) Reversal guideline
Human Prothrombin Complex Concentrate (PCC) guidance (Octaplex®)