Neuronal Antibodies

Department of Immunology

Notes

• Paraneoplastic Antibodies (Hu, Ri and Yo (Purkinje)). Also called Neuronal antibodies.
• Paraneoplastic disorders are characterised by the presence of neuronal autoantibodies. Tumours that have been known to initiate these disorders include small cell lung carcinoma, thymoma, neuroblastoma, and breast, ovarian, and testicular cancers.
• All positive results are confirmed by paraneoplastic antibody line blot.
• Test performed by Immunology, North Bristol NHS Trust.

Sample Requirements

Clotted blood.

Adult

5ml Gold-top SST tube or 3.5ml Rust-top gel tube (Trust users only)

Paediatric

1ml serum Sample

Time limit for add-on

3 days

Turnaround Times

21 days

Reference Range

Normal = Negative